Control and Prevention of Tuberculosis

Supported by USAID

Control and Prevention of Tuberculosis (CAP-TB) is a five-year project funded by the U.S. Agency for International Development (USAID) to help to reduce the incidence and mortality related to Multi-Drug Resistant TB (MDR-TB). The project supports activities in partnership with the National TB Programs (NTPs) and local organizations in Myanmar, China, and Thailand. The prime cooperating agency for the CAP-TB Project is FHI 360, with teams of professionals in each of the countries.

The project, which runs from October 2013-October 2016, aims to reduce MDR-TB-related incidence and mortality in these three target countries by:

  • Strengthening Directly Observed Therapy (DOTS) through community-based volunteers, to prevent emergence of MDR-TB
  • Increasing early case detection through the use of GeneXpert diagnostic machines for rapid diagnosis, as well as through increased referrals from the private sector
  • Improving treatment outcomes through MDR-TB “Living Support Packages” for patients, which include nutrition, transportation support, and psychosocial support.

LSHTM, in partnership with FHI, is conducting three interlinked projects under CAP-TB on incentives, gender, and economic modeling to predict effective TB/MDR-TB control and prevention in Myanmar and China.

  1. Two cross-sectional analyses of gender and its impact on incentives, which will enable a robust analysis of the program’s impact on gender disparity in TB prevalence, with the goal to inform policy/practice and enable a determination of potential implementation.
  2. A two-year case control study in Myanmar to determine risk factors associated with MDR-TB in previously treated patients and never treated patients. Embedded within this will be a determination of gender as an explanatory variable.
  3. Macro-economic modeling to determine cost-effectiveness of the project within the context of the TB control program in both China and Myanmar.

Strengthening the research network in Myanmar and China with the goal to impact health policy and implementation is expected as a result of this collaboration and body of research.

At its core, the CAP-TB project strengthens TB health systems through integration and innovation. Integration, through close alignment with the government TB control programs, ensures that the project activities will strengthen TB control and avoid parallel implementation which would challenge sustainability. Innovation is done through the introduction of new technology; inventive methods to target high-risk groups for TB/MDR-TB; and innovative clinical and health policy research. The goal is to pave the way for the government to adopt these project-implemented innovations and to use evidence-based research results in order to improve the current paradigms for TB control in a way that is sustainable and cost-effective.

The overarching goal for all project activities is to increase early case detection and to improve treatment success of TB and MDR-TB in the Greater Mekong, with eventual impact on incidence, prevalence, and mortality from these diseases.

Please visit the project website here


Collaborators include:

London School of Hygiene & Tropical Medicine
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Family Health International 360
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